Wang J, Deng X, Jian T, Yin S, Chen L, Vergnes L, Li Z, Liu H, Lee R, Lim SY, Bahn JH, Xiao X, Zhu X, Hu G, Reue K, Liu Y, Fan G. DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation. Mol Cell. 2025 May 5; doi: 10.1016/j.molcel.2025.04.019. PMID: 40328247
Deng X, Fan G. Tuning up gene transcription via direct crosstalk of DNA and RNA methylation. Mol Cell. 2025 Feb 20;85(4):674-676. doi: 10.1016/j.molcel.2025.01.030. PMID: 39983671
Zhang W, Qian S, Chen J, Jian T, Wang X, Zhu X, Dong Y, Fan G 2024 Photo-Crosslinked Pro-Angiogenic Hydrogel Dressing for Wound Healing International Journal of Molecular Sciences 25 (18), 9948
Zhang S, Xiao Y, Mo X, Chen X, Zhong J, Chen Z, Liu X, Qiu Y, Dai W, Chen J, Jin X, Fan G, Hu Y. 2024 Simultaneous profiling of RNA isoforms and chromatin accessibility of single cells of human retinal organoids Nature Communications 15 (1), 8022
Tian Z, Liu Q, Lin HY, Zhu YR, Ling L, Sung TC, Wang T, Li W, Gao M, Cheng S, Renuka RR, Subbiah SK, Fan G, Wu GJ, Higuchi A. 2024 Effects of ECM protein-coated surfaces on the generation of retinal pigment epithelium cells differentiated from human pluripotent stem cells Regenerative Biomaterials 11:rbae091. doi: 10.1093/rb/rbae091. PMID: 39233867
Xu D, Wan B, Qiu K, Wang Y, Zhang X, Jiao N, Yan E, Wu J, Yu R, Gao S, Du M, Liu C, Li M, Fan G, Yin J. 2023 Single-Cell RNA-Sequencing Provides Insight into Skeletal Muscle Evolution during the Selection of Muscle Characteristics. Adv Sci (Weinh). Dec;10(35):e2305080. doi: 10.1002/advs.202305080.
Ma L, Wang F, Li Y, Wang J, Chang Q, Du Y, Sadan J, Zhao Z, Fan G*, Yao B*, Chen JF*. Brain methylome remodeling selectively regulates neuronal activity genes linking to emotional behaviors in mice exposed to maternal immune activation. Nat Commun. 2023 Nov 29;14(1):7829. doi: 10.1038/s41467-023-43497-4.
Liu Q, Liu J, Guo M, Sung TC, Wang T, Yu T, Tian Z, Fan G, Wu W, Higuchi A. 2023. Comparison of retinal degeneration treatment with four types of different mesenchymal stem cells, human induced pluripotent stem cells and RPE cells in a rat retinal degeneration model. J Transl Med. 2023 Dec 14;21(1):910. doi: 10.1186/s12967-023-04785-1. PMID: 38098048 Free PMC article.
Tian C, Wang J, Ye X, Chen J, Zheng R, Yu H, Li J, Yin G, Liu L, Zhao N, Feng G, Zhu Z, Wang J*, Fan G*, Liu L*. Culture conditions of mouse ESCs impact the tumor appearance in vivo. Cell Rep. 2023 Jun 27;42(6):112645. doi: 10.1016/j.celrep.2023.112645. Epub 2023 Jun 13. PMID: 37314926 Free article.
Deng P, Yuan Q, Cheng Y, Li J, Liu Z, Liu Y, Li Y, Su T, Wang J, Salvo ME, Wang W, Fan G, Lyons K, Yu B, Wang CY. Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging.Cell Stem Cell. 2021 Jun 3;28(6):1057-1073.e7. doi: 10.1016/j.stem.2021.01.010. Epub 2021 Feb 10. PMID: 33571444
Wei Y, Zhang C, Fan G, Meng L. Organoids as Novel Models for Embryo Implantation Study.Reprod Sci. 2021 Jun;28(6):1637-1643. doi: 10.1007/s43032-021-00501-w. Epub 2021 Mar 1. PMID: 33650092 Review.
Jansova D, Aleshkina D, Jindrova A, Iyyappan R, An Q, Fan G, Susor A. Single Molecule RNA Localization and Translation in the Mammalian Oocyte and Embryo. J Mol Biol. 2021 Sep 17;433(19):167166. doi: 10.1016/j.jmb.2021.167166. Epub 2021 Jul 20. PMID: 34293340.
Song Y, Soto J, Wang P, An Q, Zhang X, Hong S, Lee LP, Fan G, Yang L, Li S. Asymmetric Cell Division of Fibroblasts is An Early Deterministic Step to Generate Elite Cells during Cell Reprogramming.Adv Sci (Weinh). 2021 Feb 25;8(7):2003516. doi: 10.1002/advs.202003516. eCollection 2021 Apr. PMID: 33854891
He D, Wang D, Lu P, Yang N, Xue Z, Zhu X, Zhang P, Fan G. Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations. Oncogene. 2021 Jan;40(2):355-368. doi: 10.1038/s41388-020-01528-0.
Lu P, Yang G, Jiang L, He W, Wu W, Qi L, Shen S, Rao J, Zhang P, Xue Z, Jiang C, Fan G*, Zhu X*. Characterizing disease progression of nonalcoholic steatohepatitis in Leptin-deficient rats by integrated transcriptome analysis. Exp Biol Med (Maywood). 2020 Dec 10:1535370220976530. doi: 10.1177/1535370220976530.
Lv B, An Q, Zeng, Q, Zhang X, Lu P, Wang Y, Zhu X, Ji Y*, Fan G*, Xue Z* 2019. Single-cell RNA sequencing reveals regulatory mechanism for trophoblast cell-fate divergence in human peri-implantation conceptuses. PLoS biology 17 (10), e3000187
Mao X, An Q, Xi H, Yuan S, Yang X, Wang J, Hu Y, Liu Q, Fan G*. Single cell RNA sequencing of hESC-derived 3D retinal organoids reveals novel genes regulating RPC commitment in early human retinogenesis. Stem Cell Reports. 2019 Sep 11. pii: S2213-6711(19)30306-6. doi: 10.1016/j.stemcr.2019.08.012. PMID: 31543471
Hu Y, K Huang, Q An, G Du, G Hu, J Xue, X Zhu, CY Wang, Z Xue, G Fan*. 2016. Simultaneous profiling of transcriptome and DNA methylome from a single cell. Genome Biology 17(1):88. published May 5th 2016.
Huang K, Maruyama T, Fan G. (2014) The naive state of human pluripotent stem cells: A synthesis of stem cell and premiplantation embryo transcriptome analyses. Cell Stem Cell 15(4):410-5.
Huang K, Wu Z, Liu Z, Hu G, Yu J, Chang KH, Kim KP, Le T, Faull KF, Rao N, Gennery A, Xue Z, Wang CY, Pellegrini M, Fan G. (2014). Selective demethylation and altered gene expression in human induced pluripotent stem cells and mesenchymal stem cells associated with ICF Syndrome. Human Molecular Genetics 23(24):6448-57. doi: 10.1093/hmg/ddu365. Epub 2014 Jul 15.
Huang K, Shen Y, Bibikova M, April C, Wang AY, Cheng LZ, Nagy A, Pellegrini M, Fan JB, Fan G. (2013) A panel of CG methylation sites distinguishes human embryonic stem cells and induced pluripotent stem cells. Stem Cell Reports (published online 12/26/2013).
Xue Z, Huang K, Cai C, Cai L, Jiang C-Y, Feng Y, Liu Z, Cheng L, Sun YE, Liu J-Y, Horvath S, and Fan G (2013). Genetic Programs in Human and Mouse Early Embryos Revealed by Single-Cell RNA-Sequencing. Nature 500(7464):593-7. doi: 10.1038/nature12364. Epub 2013 Jul 28.
Feng, J., Zhou, Y., Campbell, S., Le, T., Li, E., Sweatt, J.D., Silva, A.J. and Fan, G. (2010) Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nature Neuroscience V13, 423-430.
Liao JL, Yu J, Huang K, Hu J, Diemer T, Ma Z, Dvash T, Yang XJ, Travis GH, Williams DS, Bok D, Fan G. 2010. Molecular Signature of Primary Retinal Pigment Epithelium and Stem-Cell derived RPE cells. Hum Mol Genet. 19(21):4229-38. Online version on Aug 13.
Shen, Y., Chow, J., Wang, Z., Fan, G. (2006). Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells. Human Molecular Genetics. 15: 2623-2635.
Fan, G.*, Martinowich, K., Chin, M., He, F., Fouse, S., Hutnick, D., Hattori, D., Ge, W., Shen, Y., Wu, H., ten Hoeve, T., Shuai, K., and Sun, Y*. (*Corresponding authors). (2005). DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling. Development. 132: 3345-56.
Martinowich, K., Hatorri, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G*., Sun, Y*. (*Corresponding authors) (2003). DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302, 890-893.
Fan, G., Beard, C., Chen, R., Csankovszki, G., Sun, Y., Siniaia, M., Bates, B., Lee, P., Trumpp, A., Poon, C., Wilson, C., and Jaenisch, R. (2001) DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J. Neurosci. 21, 788-797.
Fan, G., Egles, C., Sun, Y., Minichiello, L., Renger, J., Klein, R., Liu, G., and Jaenisch, R. (2000) Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities. Nature Neurosci. 3, 350-357.